Gene name:
Slc27a5 (Acsb;Acsvl6;Fatp5;Vlacsr) ;
Protein name:
Bile acyl-CoA synthetase (BACS) ;
Alternative:
Cholate--CoA ligase ;Bile acid-CoA ligase (BA-CoA ligase;BAL) ;Solute carrier family 27 member 5 ;Fatty acid transport protein 5 (FATP-5) ;Very long-chain acyl-CoA synthetase-related protein (VLACS-related;VLACSR) ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation.
Subcellular Location:
Endoplasmic reticulum membrane
Multi-pass membrane protein
Protein Attributes:
50:
MGIWKKLTLL | LLLLLLVGLG | QPPWPAAMAL | ALRWFLGDPT | CLVLLGLALL |
100:
GRPWISSWMP | HWLSLVGAAL | TLFLLPLQPP | PGLRWLHKDV | AFTFKMLFYG |
150:
LKFRRRLNKH | PPETFVDALE | RQALAWPDRV | ALVCTGSEGS | SITNSQLDAR |
200:
SCQAAWVLKA | KLKDAVIQNT | RDAAAILVLP | SKTISALSVF | LGLAKLGCPV |
250:
AWINPHSRGM | PLLHSVRSSG | ASVLIVDPDL | QENLEEVLPK | LLAENIHCFY |
300:
LGHSSPTPGV | EALGASLDAA | PSDPVPASLR | ATIKWKSPAI | FIFTSGTTGL |
350:
PKPAILSHER | VIQVSNVLSF | CGCRADDVVY | DVLPLYHTIG | LVLGFLGCLQ |
400:
VGATCVLAPK | FSASRFWAEC | RQHGVTVILY | VGEILRYLCN | VPEQPEDKIH |
450:
TVRLAMGNGL | RANVWKNFQQ | RFGPIRIWEF | YGSTEGNVGL | MNYVGHCGAV |
500:
GRTSCILRML | TPFELVQFDI | ETAEPLRDKQ | GFCIPVEPGK | PGLLLTKVRK |
550:
NQPFLGYRGS | QAESNRKLVA | NVRRVGDLYF | NTGDVLTLDQ | EGFFYFQDRL |
600:
GDTFRWKGEN | VSTGEVECVL | SSLDFLEEVN | VYGVPVPGCE | GKVGMAAVKL |
650:
APGKTFDGQK | LYQHVRSWLP | AYATPHFIRI | QDSLEITNTY | KLVKSRLVRE |
689:
GFDVGIIADP | LYILDNKAQT | FRSLMPDVYQ | AVCEGTWNL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Polyclonal Antibody for Mouse BACS
Polyclonal Antibody for Mouse BACS
Polyclonal Antibody for Mouse BACS
Monoclonal Antibody for Mouse BACS
Monoclonal Antibody for Mouse BACS
Monoclonal Antibody for Mouse BACS
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
BALB/c .
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Brain .
tissue :
Salivary gland .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 28-689
4.
"Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling."
Mihalik S.J.
,
Steinberg S.J.
,
Pei Z.
,
Park J.
,
Kim do G.
,
Heinzer A.K.
,
Dacremont G.
,
Wanders R.J.
,
Cuebas D.A.
,
Smith K.D.
,
Watkins P.A.
J. Biol. Chem.277:24771-24779(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY